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目的 观察脾气虚体质大鼠的免疫学指标的变化.方法 将大鼠分为模型组和对照组,采用限制饮食结合干扰睡眠的方法来建立大鼠脾气虚体质模型.结果 模型组淋巴细胞数(LYMPH#)、淋巴细胞百分比(LYMPH%)、免疫球蛋白A (IgA)、免疫球蛋白G(IgG),环磷酸鸟苷(cGMP)均明显下降,白介素1β(IL-1β),肿瘤坏死因子α(TNF-α)均较对照组明显增加,免疫球蛋白M(IgM)、环磷酸腺苷(cAMP)无明显变化.结论 脾气虚体质者免疫功能低下.“,”Objective To observe the changes of immunological indexes in rats with spleen qi deficiency. Methods The rats were divided into two groups: model group and control group. The model of spleen qi deficiency was established by restriction diet combined with sleep disturbance. Results The lymphocyte count (LYMPH#), lymphocyte percentage (LYMPH%), immunoglobulin A (IgA), immunoglobulin G (IgG), cyclic guanosine monophosphate (cGMP) in model group were significantly lower than those in control group. The levels of interleukin -1β (IL-1β) and tumor necrosis factor-α (TNF-α) in model group were significantly higher than those in control group. There was no significant change in immunoglobulin M (IgM), cyclic adenosine monophosphate (cAMP). Conclusion The immune function of spleen qi deficiency is low.