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目的:探讨清热解毒益气方辅助放疗治疗鼻咽癌的疗效。方法:将60例鼻咽癌患者按照随机自愿的原则分为治疗组和对照组各30例。两组均接受相同放疗方案,治疗组在此基础上予清热解毒益气方。观察治疗后患者证候、体征变化,分析比较两组治疗前后急性放射性口咽黏膜反应、生活质量、行为状态以及免疫细胞变化。结果:治疗组总有效率为93.3%,高于对照组的80.0%(P<0.05);治疗组治疗后急性放射性口咽黏膜反应低于对照组(P<0.05);治疗后,两组KPS评分和QOL评分均升高(P<0.05),且治疗组高于对照组(P<0.05);治疗后CD3+、CD4+、CD4+/CD8+和NK细胞治疗组均升高(P<0.05),对照组均降低(P<0.05);治疗组治疗后CD3+、CD4+、CD4+/CD8+和NK细胞均显著高于对照组(P<0.05)。结论:清热解毒益气方辅助放疗治疗鼻咽癌,能够降低性放射性口咽黏膜反应,改善机体免疫功能,提高患者生活质量。
Objective: To investigate the curative effect of Qingre Jiedu Yiqi prescription radiotherapy on nasopharyngeal carcinoma. Methods: 60 cases of NPC patients were randomly divided into treatment group and control group according to the principle of randomness and 30 cases. Both groups received the same radiotherapy program, the treatment group on the basis of Qingrejiedu Yiqi side. After treatment, the symptoms and signs of the patients were observed. The acute radioactive oropharyngeal mucosal reaction, quality of life, behavioral status and immune cell changes were compared between the two groups before and after treatment. Results: The total effective rate in the treatment group was 93.3%, which was higher than that in the control group (80.0%, P <0.05). The acute radioactive oropharyngeal mucosa reaction in the treatment group was lower than that in the control group (P <0.05) (P <0.05), and the scores of treatment group and QOL score were higher than those of the control group (P <0.05). The levels of CD3 +, CD4 +, CD4 + / CD8 + and NK cells in treatment group were significantly increased (P <0.05). The levels of CD3 +, CD4 +, CD4 + / CD8 + and NK cells in the treatment group were significantly higher than those in the control group (P <0.05). Conclusion: Radix detoxification and Qi-invigorating prescription adjuvant radiotherapy for nasopharyngeal carcinoma can reduce the sexual radioactive oropharyngeal mucosa reaction, improve the immune function and improve the quality of life of patients.