Impact of age on host responses to diet-induced obesity:Development of joint damage and metabolic se

• 作 者: Kelsey H.Collins Graham Z.MacD
• 机 构: HumanPerformanceLaboratory,McCaigInstituteforBoneandJointHealth,DepartmentofOrthopaedicSurgery,Bone&
• 出 处: 运动与健康科学:英文版
• 发表日期: 2020年2期
• 关键词: Adult EXPOSURE HIGH-FAT high-sucrose DIET Rat OBESITY model Serum biomarkers Wea
• 基金项目: supported by the Canadian Institutes of Health Research#RT736475 and MOP 115076,the Canada Research Chair Programme,the Alberta Innovates Health Solutions Osteoarthritis Team Grant,Alberta Innovates H

Background:Osteoarthritis is one of the leading causes of pain and disability worldwide,and a large percentage of patients with osteoarthritis are individuals who are also obese.In recent years,a series of animal models have demonstrated that obesity-indu