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目的探讨垂体细胞瘤的临床表现、病理学特征和免疫组化特点。方法对4例垂体细胞瘤进行光镜下观察,通过临床随访及结合文献复习进行讨论。结果本组男性2例,女性1例,年龄45~54岁。大体表现为实性肿瘤。镜下由双极梭形细胞构成,束状交错排列,有时旋涡状。瘤细胞纺锤状至胖细胞状不等。免疫组化:肿瘤细胞vimentin、S-100和TTF-1(+),GFAP和垂体激素(-)。结论垂体细胞瘤罕见,生长缓慢,属于WHO I级。需与毛细胞型星形细胞瘤、脑膜瘤等相鉴别。
Objective To investigate the clinical manifestations, pathological features and immunohistochemical features of pituitary tumor. Methods Four cases of pituitary tumor were observed under light microscope and discussed through clinical follow-up and literature review. Results The group of 2 males and 1 females, aged 45 to 54 years. Generally manifested as solid tumors. Microscopic bipolar spindle cells formed, bundled staggered, sometimes swirling. Tumor cells ranging from spindle to fat cell. Immunohistochemistry: tumor cells vimentin, S-100 and TTF-1 (+), GFAP and pituitary hormone (-). Conclusions Pituitary tumor is rare and slowly growing and belongs to WHO class I. Need with hair cell type astrocytoma, meningioma and other phase identification.