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Recently,there have been important advancements in our understanding of thesignaling mechanisms of adrenoreceptors(AR)and signal transducers and acti-vators of transcription 3(STAT3).While their crucial roles in the pathologicalprocesses of the heart are well established,accumulating evidence suggests thereis a complex pattern of crosstalk between these 2 signaling pathways.Moreover,the potential for crosstalk occurs at multiple levels in each signaling cascade andinvolves receptor transactivation,G proteins,small GTPases,cyclic adenosine 3’,5’-monophosphate/protein kinase A,protein kinase C,scaffold/adaptor proteins,protein tyrosine kinases,and mitogen-activated protein kinases.In addition,post-translational modification(eg acetylation)of STAT3 may provide a link betweenSTAT3 and AR signaling.In particular,crosstalk between these 2 systems in theheart would appear to be dependent upon the species/tissue studied,develop-mental stage,and eliciting stimulus.This at least partly accounts for the epige-netic effects on biological function that is mediated by the 2 signaling pathways.Elucidation of these mechanisms will provide new targets in the development ofnovel clinical strategies for heart disorders.
Recently, there have been important advancements in our understanding of the signaling mechanisms of adrenoreceptors (AR) and signal transducers and acti-vators of transcription 3 (STAT3). Whilst their crucial roles in the pathological processes of the heart are well established, accumulating evidence suggests there a complex pattern of crosstalk between these 2 signaling pathways. More than two levels of each signaling cascade and involves receptor transactivation, G proteins, small GTPases, cyclic adenosine 3 ’, 5’-monophosphate / protein kinase A, protein kinase C, scaffold / adapter proteins, protein tyrosine kinases, and mitogen-activated protein kinases. addition, post-translational modification (eg acetylation) of STAT3 may provide a link between STAT3 and AR signaling.In particular, crosstalk between these 2 systems in theheart would appear to be dependent upon the species / tissue studied, develop-mental stage, and eliciting stimulus.This at least partly accounts for the epige-netic effects on biological function that is mediated by the 2 signaling pathways. Earcidation of these mechanisms will provide new targets in the development of novel clinical strategies for heart disorders.