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晚期上气消化道鳞癌多采用常规16周的长时程治疗。作者采用快速治疗方法,在8周内完成化疗、手术及放疗过程。于1985～1986共治疗12例(舌底癌5例、下咽癌2例、口腔癌4例、声门上癌1例)。年龄52～67岁,4例为低分化癌,7例为中分化癌,1例为高分化癌;Ⅲ期3例,Ⅳ期9例;随访3年以上,绝对生存率为50%。具体方法:化疗,术前5天始用顺氯氨铂100mg/kg/日静脉注入,5-Fu750mg/kg/日静脉注入,共5天,手术前一天晚上终止;在用顺氯氨铂前24小时补充氯化钾,并静脉给13.5mg甘露醇以便利尿。常规
Late upper gastro-intestinal squamous cell carcinomas were treated with conventional 16-week long-term therapy. The authors used a rapid treatment method to complete the chemotherapy, surgery and radiotherapy procedures within 8 weeks. From December 1985 to 1986, 12 cases were treated (5 cases of tongue base cancer, 2 cases of hypopharyngeal cancer, 4 cases of oral cancer, and 1 case of supraglottic cancer). Between 52 and 67 years of age, 4 cases were poorly differentiated, 7 were moderately differentiated, 1 was well-differentiated, 3 were stage III, and 9 were stage IV. The absolute survival rate was 50% after 3 years of follow-up. Specific methods: chemotherapy, 5 days before surgery with cisplatin 100mg/kg/day intravenous injection, 5-Fu750mg/kg/day intravenous injection, a total of 5 days, the night before the termination of surgery; before using cisplatin Potassium chloride was added 24 hours and 13.5 mg of mannitol was intravenously administered to facilitate urine. conventional