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目的:观察神经节苷酯钠治疗帕金森的临床疗效。方法:将2011年1月~2014年10月在我院就诊的帕金森病患者42例随机分成实验组和对照组,每组21人,实验组静脉注射神经节苷脂钠进行治疗,60mg溶于浓度为0.9%氯化钠溶液250ml,每日一次,连用两周,对照组口服美多巴进行治疗,剂量为125mg每次,每日3次。结果:治疗后,实验组和对照组两组数据进行比对得出,实验组显效9人,有效10人,轻度有效1人,无效1人,总有效率(总有效率=(显效+有效)/样本数*100%)为90.5%。对照组显效5人,有效9人,轻度有效4人,无效3人,总有效率(总有效率=(显效+有效)/样本数*100%)为66.7%。结论:神经节苷酯钠在帕金森病的治疗中是有效的,它可以成为治疗帕金森病的前途药物。
Objective: To observe the clinical effect of ganglioside sodium on Parkinson’s disease. Methods: Forty-two patients with Parkinson’s disease who were treated in our hospital from January 2011 to October 2014 were randomly divided into experimental group and control group with 21 patients in each group. The experimental group received intravenous administration of ganglioside sodium for 60mg In a concentration of 0.9% sodium chloride solution 250ml, once daily for two weeks, the control group was treated with oral methadone, a dose of 125mg each time, 3 times a day. Results: After treatment, the experimental group and the control group two groups of data were compared, the experimental group markedly effective 9, effective 10, 1 mild, 1 invalid, the total effective rate (total effective = (markedly effective + Valid) / number of samples * 100%) is 90.5%. In the control group, 5 were markedly effective, 9 were effective, 4 were mildly effective and 3 were ineffective. The total effective rate (total effective rate = (markedly effective + effective) / sample number * 100%) was 66.7%. CONCLUSIONS: Ganglioside sodium is effective in the treatment of Parkinson’s disease and can be a promising drug for the treatment of Parkinson’s disease.