Molecular mechanism of signaling by tumor necrosis factor

• 作 者: 查纪坤 舒红兵
• 出 处: Science in China(Series C:Life Sciences)
• 发表日期: 2002年02期
• 关键词: tumor necrosis factor signal transduction JNK kinase NF-κB apoptosis

Tumor necrosis factor (TNF) is an important cytokine with multiple biological effects, including cell growth, differentiation, apoptosis, immune regulation and induction of inflammation. The effects of TNF are mediated by two receptors, TNF-R1 and TNF-R2. The major signal trans-duction pathways triggered by TNF include those that lead to apoptosis, activation of transcription factor NF-κB and protein kinase JNK. This review will discuss the molecular mechanisms of these signaling pathways.

Tumor necrosis factor (TNF) is an important cytokine with multiple biological effects, including cell growth, differentiation, apoptosis, immune regulation and induction of inflammation. The effects of TNF are mediated by two receptors, TNF-R1 and TNF-R2. The major signal trans-duction pathways triggered by TNF include those that lead to apoptosis, activation of transcription factor NF-κB and protein kinase JNK. This review will discuss the molecular mechanisms of these signaling pathways.