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目的了解深圳龙华新区HIV感染者和艾滋病患者的流行病学特点,探讨艾滋病抗病毒治疗对患者生存时间的影响。方法采用2005~2012年全国疾病监测信息报告管理系统报告的数据进行趋势及描述性分析,运用Ka-plan-Meier曲线分析艾滋病患者接受抗病毒治疗后对其生存时间的影响。结果 2005~2012年累计报告艾滋病453例,其中艾滋病病人112例,HIV感染者341例,2005~2012年间,艾滋病发病(含HIV感染)率呈上升趋势(χ2=94.33,P=0.000),艾滋病(含HIV感染)在新区传染病中的比例也呈上升趋势(χ2=81.46,P=0.000)。所有患者中,HIV感染者男女性别比为6.1:1,AIDS患者男女性别比为2.6:1,85.43%患者感染途径为性接触感染。运用Kaplan-Meier曲线分析艾滋病患者接受抗病毒治疗后对其生存时间的影响,发现经抗病毒治疗后,艾滋病患者的1、6、12个月累积生存率分别为99.3%、98.2%、98.2%,明显高于未治疗组的88.0%、77.7%、69.9%(χ2=35.256,P<0.001)。结论深圳龙华新区艾滋病发病呈上升趋势,抗病毒治疗能有效提高艾滋病患者生存率。
Objective To understand the epidemiological characteristics of HIV-infected and AIDS-infected patients in Longhua New Area of Shenzhen and to explore the impact of HIV antiviral therapy on the survival time of patients. Methods The data of the national disease surveillance information report management system from 2005 to 2012 were used to analyze the trend and descriptive analysis. The Ka-plan-Meier curves were used to analyze the impact of anti-virus treatment on the survival time of AIDS patients. Results A total of 453 AIDS cases were reported from 2005 to 2012, of which 112 were AIDS and 341 were HIV-infected. The prevalence of HIV infection (including HIV infection) increased from 2005 to 2012 (χ2 = 94.33, P = 0.000) (Including HIV infection) in infectious diseases in the New District also showed an upward trend (χ2 = 81.46, P = 0.000). In all patients, the male-to-female sex ratio of HIV-infected patients was 6.1: 1, and the male-to-female sex ratio of AIDS patients was 2.6: 1. 85.43%. The infection route was sexual contact infection. The Kaplan-Meier curves were used to analyze the impact of antiviral therapy on the survival time of AIDS patients. The cumulative survival rates of AIDS patients after 1, 6 and 12 months were 99.3%, 98.2% and 98.2% respectively after antiviral therapy. , Which was significantly higher than 88.0%, 77.7% and 69.9% of untreated patients (χ2 = 35.256, P <0.001). Conclusion The incidence of AIDS in Longhua New Area in Shenzhen is on the rise. Antiviral treatment can effectively improve the survival rate of AIDS patients.