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采用病例对照研究方法， 对广西５个地级市及郊区１２８６ 例先天性心脏病患儿和对照组进行流行病学调查，所得资料在单因素分析的基础上， 用条件ｌｏｇｉｓｔｉｃ回归模型进行多因素综合分析， 筛选与儿童先天性心脏病发病关系密切的危险因素。分析结果表明， 母亲孕期年龄偏大 （ＯＲ＝ ５．２２）、父亲饮酒 （ＯＲ＝ ２．１２）、母亲孕早期服用阿司匹林（ＯＲ＝ ４．４５）、服四环素类药物 （ＯＲ＝ ２．８９）、服避孕药（ＯＲ＝ ５．５８）、接触化学毒物（ＯＲ＝ ７．６０）、罹患风疹（ＯＲ＝２．２３） 和感冒 （ＯＲ＝ ８．２１） ８ 个因素是先天性心脏病发病的危险因素
A case-control study was conducted to investigate the prevalence of 1286 cases of congenital heart disease and control group in five prefecture-level cities and suburbs in Guangxi province. The data obtained were analyzed by conditional logistic regression model on the basis of univariate analysis. Comprehensive analysis, screening and risk factors for children with congenital heart disease. The results showed that mothers were older (OR = 5.22), their father drinking (OR = 2.12), their mothers taking aspirin during the first trimester (OR = 4.45) and taking tetracyclines (OR = 2.89 (OR = 5.58), exposure to chemical toxins (OR = 7.60), rubella (OR = 2.23) and cold (OR = 8.21) were the most common causes of congenital heart disease Risk factors for the disease