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有一些的细胞的原癌基因在化学或者是物理的一些致癌的因子的作用下,在一些特定的位置发生单个碱基替换的位置点发生突变而被激活为致癌的基因,从而合成异常的蛋白质,引发细胞的癌变。研究表明在一些癌细胞中很容易地发现原癌基因可以拷贝的数量大大的增加,这也就表明了癌基因的一个扩增。由于原癌基因的一个大量的扩增,会使得其的转录的水平比正常的细胞高很多,这也是导致细胞癌变的一个原因之一。
Some of the cellular proto-oncogenes are under the action of some chemical or physical oncogenic factors and are mutated to sites of single base substitution at specific positions to be activated as oncogenic genes to synthesize abnormal proteins , Triggering cancerous cells. Studies have shown that in some cancer cells it is easy to find that the number of copies of proto-oncogenes is dramatically increased, indicating an amplification of oncogenes. Due to a large number of proto-oncogene amplification, will make its transcription level much higher than normal cells, which is one of the reasons leading to cancer cells.