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随着人类的进步,人口老龄化的趋势日益严重。一项针对12 380例健康人的全外显子测序显示,年龄大于65岁老年人的克隆造血发生率明显高于年轻人,这表明机体衰老会带来血液衰老,并带来更高的血液肿瘤发生率~([1])。现实世界的数据也表明,不论是急性白血病、淋巴瘤还是多发性骨髓瘤,血液肿瘤的发生率都随着年龄明显增加,特别是在50岁以后。但是,老年血液肿瘤的治疗是
With the progress of mankind, the population aging trend is getting worse. A total exome sequencing of 12 380 healthy people showed that the incidence of clonal hematopoiesis was significantly higher in older adults than 65 years of age, suggesting that senescence of the body will lead to blood aging and bring about higher blood Tumor incidence ~ ([1]). Real-world data also show that, whether acute leukemia, lymphoma or multiple myeloma, the incidence of hematological tumors are significantly increased with age, especially after the age of 50. However, the treatment of elderly hematological tumors is