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高迁移率族蛋白1(HMGB1)是一种高度保守的核蛋白,普遍存在于哺乳动物细胞。最近发现可由激活的单核/巨噬细胞等主动分泌或由坏死细胞被动释放到细胞外,在感染及炎症时血浆HMGB1水平显著升高,起到重要的促炎效应,包括激活单核/巨噬细胞产生多种细胞因子,诱导内皮黏附分子的表达及损伤上皮细胞屏障功能等;可引起发热和厌食,参与多种疾病尤其是脓毒症、关节炎、结肠炎等发病过程。在“早期”炎症介质释放后,给予抗HMGB1抗体,仍可对致命性内毒素血症、脓毒症及急性肺损伤动物发挥保护作用,为临床提供了更加宽广的治疗时机与新的干预途径。
High mobility group box 1 (HMGB1) is a highly conserved nuclear protein that is ubiquitous in mammalian cells. Recently, it has been found that it can be actively secreted by activated monocytes / macrophages, etc. or passively released from necrotic cells to the outside of the cell. In the case of infection and inflammation, the plasma HMGB1 level is significantly elevated and plays an important proinflammatory effect, including activation of monocytes / macrophages Macrophages produce a variety of cytokines, induce the expression of endothelial adhesion molecules and damage the epithelial cell barrier function; can cause fever and anorexia, involved in a variety of diseases, especially sepsis, arthritis, colitis and other pathogenesis. After the release of “early” inflammatory mediators, administration of anti-HMGB1 antibodies can still protect animals from lethal endotoxemia, sepsis and acute lung injury, providing a broader therapeutic opportunity and new interventional route for clinical use .