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目的:观察长蛇灸联合西药治疗心肾阳虚型慢性心力衰竭的临床疗效.方法:将80例患者随机分为对照组和观察组,每组40例.对照组予常规西药治疗,观察组在此基础上加用长蛇灸治疗.治疗前后测定左室射血分数(LVEF)、每搏量(SV)及左室舒张末期内径(LVEDd),评定心功能等级;测定血清脑钠肽(BNP)水平,记录6 min步行距离,评定明尼苏达心功能不全生存质量量表(MLHFQ)评分,检测血清半乳糖凝集素-3(Gal-3)及可溶性生长刺激表达基因2蛋白(sST2)水平.治疗后评价临床疗效.结果:观察组总有效率高于对照组,组间差异有统计学意义(P<0.05).治疗后,两组LVEF、SV及LVEDD均较治疗前显著改善(均P<0.05),观察组LVEF、SV及LVEDD均优于对照组(均P<0.05);两组心功能分级均较治疗前改善(均P<0.05),观察组心功能分级优于对照组(P<0.05);两组血清BNP水平均降低(均P<0.05),观察组血清BNP水平低于对照组(P<0.05);两组6 min步行距离及MLHFQ评分均改善(均P<0.05),且观察组6 min步行距离及MLHFQ评分均优于对照组(均P<0.05);观察组血清Gal-3及sST2水平均显著降低(均P<0.05),且均低于对照组(均P<0.05).结论:长蛇灸联合西药治疗心肾阳虚型慢性心力衰竭疗效显著,可改善心功能,降低血清BNP水平,提升患者运动耐力及生存质量,这可能与其下调血清Gal-3及sST2水平有关.“,”Objective: To observe the clinical efficacy of long-snake moxibustion plus Western medicine for chronic heart failure due to heart-kidney yang deficiency.Methods: A total of 80 patients were randomized into a control group and an observation group, with 40 cases in each group. The control group was treated with routine Western medicine, and the observation group was treated with long-snake moxibustion therapy on the basis of routine Western medicine. Left ventricular ejection fraction (LVEF), stroke volume (SV) and left ventricular end-diastolic diameter (LVEDd) were measured before and after treatment, and the heart function was assessed. The serum brain natriuretic peptide (BNP) level was measured, the 6 min walking distance was recorded, and the Minnesota living with heart failure questionnaire (MLHFQ) was assessed and scored. The serum galectin-3 (Gal-3) and soluble growth stimulation expressed gene 2 (sST2) protein levels were measured. Clinical efficacy was evaluated after treatment. Results: The total effective rate of the observation group was higher than that of the control group, and the difference between the two groups was statistically significant (P<0.05). After treatment, LVEF and LVEDd in both groups were significantly improved (all P<0.05), and LVEF, SV and LVEDd in the observation group were superior to those in the control group (all P<0.05). The heart function classification in both groups were improved after treatment (both P<0.05), and the heart function classification in the observation group was superior to that in the control group (P<0.05). The serum BNP level in both groups decreased (both P<0.05), and the serum BNP level in the observation group was lower than that in the control group (P<0.05). The 6 min walking distance and MLHFQ scores in both groups were improved (all P<0.05), and the 6 min walking distance and MLHFQ score in the observation group were superior to those in the control group (both P<0.05). The serum Gal-3 and sST2 levels in the observation group decreased significantly (both P<0.05), and all lower than those in the control group (both P<0.05). Conclusion: Long-snake moxibustion plus Western medicine has significant efficacy in treating chronic heart failure due to heart-kidney yang deficiency; it can improve heart function, reduce the serum BNP level, and improve the exercise endurance and quality of life in the patients. This may be related to the down-regulation of serum Gal-3 and sST2 levels.