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目的:探讨血管内皮生长因子(VEGF)、癌基因c-erbB-2在胃癌组织中表达及其临床特征之间的关系。方法:应用免疫组化技术,检测102例人胃癌组织中VEGF、c-erbB-2蛋白表达,分析VEGF、c-erbB-2与胃癌组织学分型、浸润深度、生长方式、淋巴结转移和预后的关系。结果:102例胃癌组织中VEGF表达阳性率为50%(51/102)与胃癌浸润深度(P<0.01)、生长方式(P<0.01)、淋巴结转移(P<0.01)密切相关,而与组织学类型无关(P>0.05)。102例胃癌组织中c-erbB-2表达阳性率为38.24%(39/102),与胃癌浸润深度(P<0.05)、淋巴结转移(P<0.05)密切相关,而与组织学类型及生长方式无关(P>0.05)。生存期分析显示VEGF和c-erbB-2阳性的胃癌患者预后差,VEGF表达阳性的或c-erbB-2表达阳性的胃癌患者5年生存率较低。结论:VEGF、c-erbB-2与胃癌的生长、浸润、转移、预后均有密切关系,同时进行VEGF和c-erbB-2免疫组化检测对于评估胃癌的预后会更有意义。
Objective: To investigate the relationship between the expression of vascular endothelial growth factor (VEGF) and oncogene c-erbB-2 in gastric carcinoma and their clinical features. Methods: The expressions of VEGF and c-erbB-2 protein in 102 cases of gastric cancer were detected by immunohistochemistry. The expressions of VEGF, c-erbB-2 and histological type, depth of invasion, growth pattern, lymph node metastasis and prognosis relationship. Results: The positive rate of VEGF expression in 102 gastric cancer tissues was 50% (51/102), which was closely related to the depth of invasion (P <0.01), growth mode (P <0.01) and lymph node metastasis Learning type has nothing to do (P> 0.05). The positive rate of c-erbB-2 in 102 gastric cancer tissues was 38.24% (39/102), which was closely related to the depth of invasion (P <0.05) and lymph node metastasis (P <0.05), but not to the histological type and growth pattern Not related (P> 0.05). Survival analysis showed that patients with VEGF and c-erbB-2-positive gastric cancer had a lower 5-year survival rate in patients with poor prognosis, gastric cancer with positive VEGF expression or positive c-erbB-2 expression. Conclusions: VEGF, c-erbB-2 are closely related to the growth, invasion, metastasis and prognosis of gastric cancer. It is more meaningful to evaluate the expression of VEGF and c-erbB-2 by immunohistochemistry in the evaluation of prognosis of gastric cancer.