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[目的]了解郑州市志贺菌的菌型分布,为防控菌痢流行提供可靠数据。[方法]按照《全国细菌性痢疾监测工作方案》对郑州市市辖医院2005~2007年腹泻患者粪便标本进行志贺菌分离培养、生化鉴定和血清学分型以及药敏试验。[结果]2005~2007年郑州市共检测1 321份标本,检出志贺菌116株,检出率为8.78%。志贺菌分布在福氏和宋內氏2个群,未检出A群和C群。不同年份间菌株均以B群志贺菌为主,分别为39、37和21株,分别占当年阳性菌株的92.86%、77.08%、80.77%;福氏志贺菌以F4c(47株)为主,占48.45%,其次是F1a(21株)、F2a(17株),分别占21.65%和17.53%;志贺菌对萘啶酸和四环素100.00%耐药。[结论]各年优势菌群均为福氏志贺菌,F4c为优势菌型,多种菌型并存,临床治疗要根据耐药情况合理使用抗生素。
[Objective] To understand the distribution of Shigella bacteria in Zhengzhou and provide reliable data for the prevention and control of the bacillary dysentery epidemic. [Methods] According to the “National Bacterial Dysentery Surveillance Program”, Shigella isolation and culture, biochemical identification, serological typing and drug susceptibility tests of diarrhea patients in Zhengzhou municipal hospital from 2005 to 2007 were conducted. [Results] A total of 1 321 specimens were detected in Zhengzhou from 2005 to 2007, and 116 strains of Shigella were detected, the detection rate was 8.78%. Shigella was distributed in two groups, Frees and Songneas, but no A and C were detected. The strains of Shigella flexneri in group B were mainly 39, 37 and 21 strains, accounting for 92.86%, 77.08% and 80.77% of the positive isolates of the year respectively. The F4c (47 strains) Main, accounting for 48.45%, followed by F1a (21 strains) and F2a (17 strains), accounting for 21.65% and 17.53% respectively; Shigella is 100% resistant to nalidixic acid and tetracycline. [Conclusion] The dominant bacteria in each year were all Shigella flexneri. F4c was the predominant bacterium, and many kinds of bacteria co-existed. The clinical treatment should use antibiotics reasonably according to the resistance.