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３０只ＳＤ大鼠随机分成三组，在给大鼠腹腔注射链脲佐菌素（５５ｍｇ／ｋｇ体重）前３天，分别予以生理盐水喂服、烟酰胺（１ｇ·ｋｇ体重－１／天）喂服和肌注，并连续用药两周。结果显示，用生理盐水喂服的大鼠，在注射链脲佐菌素后全部出现持续稳定的高血糖（＞１６．６ｍｍｏｌ／Ｌ），２４小时尿糖量明显高于正常（Ｐ＜０．００１），形态学检查显示胰岛萎缩，β细胞数量下降；用药大鼠禁食血糖与２４小时尿糖量均正常或接近正常，胰岛形态与β细胞功能均与正常大鼠无显著性差异，表明烟酰胺对链脲佐菌素引致糖尿病有较好的防治作用。
Thirty Sprague-Dawley rats were randomly divided into three groups. Three days before the intraperitoneal injection of streptozotocin (55 mg / kg body weight), they were given normal saline and niacinamide (1 g · kg -1) Feeding and intramuscular injection, and continuous medication for two weeks. The results showed that rats fed with saline all showed sustained and stable hyperglycemia (> 16.6mmol / L) after streptozotocin injection, and the urine sugar in 24 hours was significantly higher than normal (P <0. 001). Morphological examination showed islet atrophy and decreased number of β-cells. The fasting blood glucose and 24-hour urine glucose of rats in treatment group were all normal or close to normal, and there was no significant difference between islet morphology and β-cell function in normal rats Nicotinamide on streptozotocin caused diabetes better prevention and treatment.