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肺结核曾是广泛流行的慢性呼吸道传染病。由于采用综合性防治措施,尤其是合理应用抗结核药物,肺结核的流行已逐年减少。但欲彻底消灭结核病,尚须进行很大的努力。面对结核病流行减少的现状,某些地区推荐采用异烟肼预防性治疗(IPT),作为预防肺结核的重要措施,取得一定效果,但在应用中亦遇到异烟胼引起肝功能障碍的问题。本文拟综述IPT的实用价值和副作用,探讨合理可行的IPT方案。
Tuberculosis was a widespread epidemic of chronic respiratory disease. The prevalence of tuberculosis has been declining year by year due to the adoption of comprehensive prevention and treatment measures, especially the rational use of anti-tuberculosis drugs. However, great efforts are still needed to completely eliminate tuberculosis. Faced with the current situation of the reduction of tuberculosis, IPT is recommended in some areas as an important measure to prevent tuberculosis and has achieved certain results. However, it has also encountered the problem of liver dysfunction caused by isoniae corpuscles in some areas . This article intends to summarize the practical value of IPT and side effects, to explore a reasonable and feasible IPT program.