Design,Synthesis,Biological Evaluation and SARs of Anthranilic Diamide Derivatives Containing Pyrrol

• 作 者: ZHAO Yangyang LI Huangong SUN Pengwei GAO Li ZHOU Sha XIONG Lixia YANG Na LI Yuxin LI Zhengming
• 机 构: State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry,Nankai U
• 出 处: 高等学校化学研究（英文版）
• 发表日期: 2020年6期
• 关键词: Ryanodine receptors(RyRs)activator Pyrrole Anthranilic diamide Insecticidal acti

In order to find a new variety of ryanodine receptor(RyR)regulator with greater biological activity,a se-ries of anthranilic diamide derivatives possessing pyrrole structure was designed and synthesized in this study.The pyrrole derivatives were evaluated for their insecticidal activity against Mythimna separata and Plutella xylostella.As indicated by the preliminary biological activities,compounds 12h-12j and 121-12n exhibited a remarkable in-secticidal activity against M.separata at 0.25 mg/L.Compared to control chlorantraniliprole,compound 12j exhibited more excellent insecticidal activity at 0.1 mg/L.Meanwhile,compounds 12c,12h,12i,12j,121,and 12m were se-lected to test the insecticidal activity against P.xylostella,which led to the desirable insecticidal activity at 1×10-3 mg/L.Notably,compound 121 demonstrated 47％insecticidal activity at 5×10-6 mg/L over the control.In addition,the biological mechanism of action of compound 12j was investigated by means of insect electrophysiology experiment.