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目的:探讨C-反应蛋白(CRP)在2型糖尿病(T2DM)大血管并发症患者血清中的作用及临床价值。方法:T2DM患者分为大血管并发症组(观察组)和无大血管并发症组(对照组)各45例,测定患者CRP浓度、空腹静脉血糖(FPG)、糖化血红蛋白(HbAlc)、空腹胰岛素(Fins)和血脂水平,记录血压水平和体重指数(BMI)。结果:(1)观察组血清CRP浓度和血压水平明显高于对照组,相比较有统计学差异(P<0.05);而两组FPG水平和HbAlc值差异无统计学意义(P>0.05)。(2)观察组血清TG、Fins水平和BMI明显高于对照组,相比较有统计学差异(P<0.05);而血清两组HDL-C、LDL-C水平差异无统计学意义。结论:联合检测血清CRP及血压、血脂、体质量及胰岛素等指标,对于T2DM大血管并发症患者的早期诊断、预防、治疗及预后评价具有重要的临床意义。
Objective: To investigate the role of C-reactive protein (CRP) in the serum of patients with macrovascular complications of type 2 diabetes mellitus (T2DM) and its clinical value. Methods: The patients with T2DM were divided into two groups: macrovascular complications (observation group) and non-macrovascular complications group (control group), 45 cases each. CRP concentration, fasting venous blood glucose (FPG), HbAlc, fasting insulin (Fins) and lipid levels, blood pressure levels and body mass index (BMI) were recorded. Results: (1) The levels of serum CRP and blood pressure in the observation group were significantly higher than those in the control group (P <0.05). There was no significant difference between the two groups in the level of FPG and HbAlc (P> 0.05). (2) The levels of serum TG, Fins and BMI in the observation group were significantly higher than those in the control group (P <0.05). There was no significant difference in HDL-C and LDL-C between the two groups. Conclusion: The combined detection of serum CRP, blood pressure, blood lipid, body weight and insulin levels has important clinical significance for the early diagnosis, prevention, treatment and prognosis evaluation of T2DM patients with macrovascular complications.