【摘 要】
：
苯并咪唑稠合二氢苯并唑是一类复杂的氮氧杂环,在生物医药和功能性材料中具有较高的应用价值.本文在空气氛围中以苯并咪唑和2-溴苯酚为原料、廉价Cu(Ⅱ)为催化剂,采用“一锅
【机 构】
：
西南大学化学化工学院生物有机与药物化学研究所重庆市高校应用化学重点实验室,北京分子科学国家实验室,
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苯并咪唑稠合二氢苯并唑是一类复杂的氮氧杂环,在生物医药和功能性材料中具有较高的应用价值.本文在空气氛围中以苯并咪唑和2-溴苯酚为原料、廉价Cu(Ⅱ)为催化剂,采用“一锅法”合成了苯并咪唑稠合二氢苯并唑类化合物,反应经历了N-芳基化、sp~2 C-H活化、C-O环化的串联过程.研究表明,该反应对于苯并咪唑类衍生物,以及其他反应底物(如2-碘苯酚和2-羟基苯硼酸)均具有一定的官能团耐受性.本文为高效合成苯并咪唑稠合二氢苯并唑类化合物提供了一种简便方法.
Benzimidazole fused dihydrobenzoxazole is a kind of complex nitroxide, which has high application value in biomedical and functional materials.In this paper, benzimidazole and 2-bromophenol are used as Benzimidazole fused dihydrobenzoxazoles were synthesized by the one-pot method using Cu (Ⅱ) as raw material and cheap Cu (Ⅱ) as catalysts. The reaction underwent N-arylation, sp ~ 2 CH activation, The results show that the reaction has certain functional group tolerance to benzimidazole derivatives and other reactive substrates such as 2-iodophenol and 2-hydroxybenzeneboronic acid.In this paper, And imidazole fused dihydrobenzoxazole compounds provide a convenient method.
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