论文部分内容阅读
CD40和CD40L在组织中的表达水平以及CD40与CD40L间的结合反应对启动体液和细胞免疫应答起着重要作用;CD40的持续表达和CD40L的表达缺失可能与肿瘤的发生以及肿瘤的免疫逃逸相关;将CD40L基因转染肿瘤细胞可使表达CD40肿瘤细胞的抗原提呈功能增强,使机体产生肿瘤细胞特异性CTL反
The expression level of CD40 and CD40L in tissues and the binding reaction between CD40 and CD40L play an important role in the initiation of humoral and cellular immune responses. The persistent expression of CD40 and the loss of CD40L expression may be related to tumorigenesis and tumor immune escape. Transfection of CD40L gene into tumor cells can enhance the antigen presenting function of CD40 expressing tumor cells and make the body produce CTL