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目的观察免疫抑制药物对慢性脑血管痉挛的预防作用。方法采用本单位以往建立的犬“二次蛛网膜下腔出血”模型，观察硫唑嘌呤对慢性脑血管痉挛的预防作用。结果在蛛网膜下腔出血第７天，硫唑嘌呤组的基底动脉口径为（８７.１±２５．９）％，管壁ＭＤＡ含量为０．０３±０．０１ｎｍｏｌ／ｍｇ；而安慰剂组的血管口径为（５２．７±１７．１）％，ＭＤＡ含量为０．１０７±０．０５ｎｍｏｌ／ｍｇ。组织学检查发现硫唑嘌呤组的血管壁结构破坏明显较安慰剂组轻。结论蛛网膜下腔出血后慢性脑血管痉挛主要是免疫系统参与的炎症反应的结果，抗炎抗免疫疗法能有效预防慢性脑血管痉挛。
Objective To observe the preventive effect of immunosuppressive drugs on chronic cerebral vasospasm. Methods The model of secondary subarachnoid hemorrhage established by this unit was used to observe the preventive effect of azathioprine on chronic cerebral vasospasm. Results In the 7th day after subarachnoid hemorrhage, the basilar artery caliber of azathioprine group was (87.1 ± 25.9)%, the content of MDA in the wall was 0.03 ± 0.01 nmol / mg, while the placebo group The vascular diameter was (52.7 ± 17.1)%, MDA content was 0.107 ± 0.05nmol / mg. Histological examination revealed that the destruction of the vascular wall structure in the azathioprine group was significantly less than in the placebo group. Conclusions Chronic cerebral vasospasm following subarachnoid hemorrhage is mainly caused by the inflammatory reaction involved in the immune system. Anti-inflammatory and anti-immunotherapy can effectively prevent chronic cerebral vasospasm.