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目的:探讨中药肝炎平对急性肝损害的防护作用。方法:用D-氮基半乳糖(D-GalN)制各大鼠急性肝损伤模型,检测血清丙氨酸转氮酶活性(ALT)、肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)和白细胞介素8(IL-8)浓度的变化。结果:肝损伤组ALT活性为2442.2±445.1nmol/L,TNF-α浓度为8.07±1.93ng/L,IL-6浓度为2.56±0.87ng/ml,IL-8浓度为5.78±2.12ng/ml;肝炎平组分别为1258.6±468.4nmol/L、0.63±0.27ng/L、0.52±0.13ng/ml、1.28±0.72ng/ml,各细胞因子水平均较肝损伤组明显降低(P<<0.01)。结论:肝炎平可通过对免疫机制的调节,而降低TNF-α、IL-6和IL-8等细胞因子的生成和释放。
Objective: To investigate the protective effect of traditional Chinese medicine Heyanping on acute liver injury. METHODS: Rat acute liver injury model was established with D-galactosamine (D-GalN) to detect serum alanine nitrogenase (ALT), tumor necrosis factor-α (TNF-α), and interleukin Changes in concentrations of 6 (IL-6) and interleukin 8 (IL-8). Results: The ALT activity in the liver injury group was 2442.2±445.1 nmol/L, the TNF-α concentration was 8.07±1.93 ng/L, the IL-6 concentration was 2.56±0.87 ng/ml, and the IL-8 concentration was 5.78±2.12 ng/ml Hepatitis group was 1258.6±468.4 nmol/L, 0.63±0.27 ng/L, 0.52±0.13 ng/mL, and 1.28±0.72 ng/mL, respectively, and the levels of cytokines were significantly lower than those in the liver injury group (P<0.01). ). Conclusion: Hepingyan can reduce the production and release of cytokines such as TNF-α, IL-6 and IL-8 through the regulation of immune mechanism.