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生物质谱技术是近年来发展较为迅速的生物分析技术之一,在对大分子生物质量测定中,其以快速、准确、灵敏等优点受到研究者的青睐。其中,液相电喷雾离子电离质谱(LC-ESI-MS)在法医DNA分析中对STR以及SNP遗传标记的检测具有独特的应用价值和广阔的应用前景。本文对ESI-MS的现状和在法医DNA分析中的应用等方面进行了综述,分析了LC-ESI-MS技术在法医学DNA分析中的优缺点,以促进其在国内法医DNA分析中的应用与发展。
Biomass spectrometry technology is one of the more rapid bioanalysis techniques developed in recent years. It has been favored by researchers for its rapid, accurate and sensitive detection of macromolecular biological quality. Among them, liquid-phase electrospray ionization mass spectrometry (LC-ESI-MS) has unique application value and broad application prospect in the detection of STR and SNP genetic markers in forensic DNA analysis. The current status of ESI-MS and its application in forensic DNA analysis are reviewed. The advantages and disadvantages of LC-ESI-MS in forensic DNA analysis are analyzed in order to promote its application in forensic DNA analysis in China. development of.