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目的:研究旨在评估闭环刺激（closed-loop stimulation，CLS）功能对快速房性心律失常的干预作用。方法:入选2016年8月至2018年3月在中日友好医院植入CLS功能双腔起搏器的患者30例（男18例），年龄（64.3±14.7）岁，年龄范围47~89岁。简单随机法分为A组（先DDD-CLS模式后DDDR模式，每种模式3个月）和B组（先DDDR模式后DDD-CLS模式，每种模式3个月），并采取单盲、自身交叉对照原则，分别观察并比较两种模式的心房及心室起搏比例、自动模式转换（AMS）次数及持续时间和房性心动过速（房速）负荷百分比。结果:与DDDR模式相比，DDD-CLS模式下心房起搏比例更高（66.5%±11.8%对55.8%±14.0%，n OR=1.30，95%n CI 1.06~1.73，n P=0.007）、AMS次数更少[（369±409）次对（596±761）次，n OR=0.62，95%n CI 0.32~0.88，n P=0.025]、房速负荷更低（17.9%±3.6%对29.3%±7.3%，n OR=0.61，95%n CI 0.18~0.71，n P=0.034）。n 结论:CLS功能可能具有降低双腔心脏起搏器术后患者快速房性心律失常负荷的作用。“,”Objective:To observe the effect of closed-loop stimulation (CLS) on rapid atrial arrhythmia.Methods:From August 2016 to March 2018, 30 patients with CLS dual chamber pacemaker implanted in China-Japan Friendship Hospital were selected in this study. The average age was (64.3±14.7) years, including 18 males. The patients were divided into A group (DDD-CLS mode before DDDR mode, both mode for 3 months) and B group (DDDR mode before DDD-CLS mode, both mode for 3 months) by simple randomization with single blind and crossover design.We observed and compared the percentage of atrial and ventricular pacing rate and the frequency and duration of auto mode switch (AMS) and atrial tachycardia burden percentage of the same patient under DDD-CLS mode and DDDR mode by pacemaker programmer.Results:Comparing to DDDR mode, DDD-CLS mode showed higher atrial pacing rate (66.5%±11.8% vs. 55.8%±14.0%, n OR=1.30, 95%n CI 1.06-1.73, n P=0.007) , lower AMS counts[ (369±409) times vs. (596±761) times, n OR=0.62, 95%n CI 0.32-0.88, n P=0.025]and lower atrial tachycardia burden percentage (17.9%±3.6% vs.29.3%±7.3%,n OR=0.61, 95%n CI 0.18-0.71, n P=0.034) .n Conclusion:CLS function may reduce the rapid atrial arrhythmia burden in patients treated with permanent dual chamber pacemaker.