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目的:探讨缺血预适应(IPC)对缺血再灌注(I/R)损伤无复流现象的保护作用及可能机理.方法:应用离体大鼠心脏全心I/R损伤模型,20只WISTAR大鼠被随机分为I/R对照组和IPC组,观察冠脉流出液中MDA及NO含量、无复流区域所占面积百分比、心脏微循环等指标的变化.结果:IPC组较I/R对照组冠脉流出液中NO含量显著增高(P＜0.01),MDA含量明显降低(P＜0.005),无复流区域所占面积百分比明显减少(P＜0.0005),心脏微循环的损伤也较轻.NO含量和MDA含量有明显负相关关系(R＝－0.909,P＜0.01).结论:IPC对无复流现象有保护作用,可能与其抗氧化、保护内源性NO释放有关.“,”Obijective: This paper was to study the protective effects and possible mechanism of ischemic preconditioning (IPC) on no reflow phenomenon. Methods: We established isolated rat heart model with ischemia and refusion (I/R) injury. Twenty wistar rats were randomly assigned to I/R control group and IPC group. Methylenedioxyamphetamine (MDA) and nitric oxide (NO) content in coronary effluent fluid, area of no reflow (%) and heart microcirculation were detected or observed during the course of I/R in control ...