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目的探讨原发性高血压患者脉压(PP)、SBP、DBP及平均动脉压(MA P)与早期肾损害的关系。方法选择120例原发性高血压患者进行PP、SBP、DBP和MAP检查,以血β~2微球蛋白(β_2-MG)水平>2.6 mg/L作为肾损害的标准,分为肾损害组和非肾损害组,其中,肾损害组56例,非肾损害组64例。将两组血压参数进行比较,并与血、β_2-MG水平进行相关性分析。结果肾损害组PP(58±10 mmHg)及SBP(165±28mmHg)较非肾损害组(42±8mmHg)、(152±10mmHg)明显增高。相关分析显示血β_2-MG与PP、SBP呈正相关,尿β_2-MG与PP、SBP、DBP、MAP呈正相关。其中与PP、SBP相关性较好。结论 PP与SBP、DBP、MAP增高均可导致高血压患者早期肾损害,而PP、SBP增大是导致高血压患者早期肾损害的主要因素。
Objective To investigate the relationship between pulse pressure (PP), SBP, DBP and mean arterial pressure (MA P) and early renal damage in patients with essential hypertension. Methods A total of 120 essential hypertension patients were selected for PP, SBP, DBP and MAP examinations. The levels of serum β-2 microglobulin (β_2-MG)> 2.6 mg / L were used as the criteria of renal impairment. And non-renal impairment group, of which 56 cases were renal damage group and 64 cases were non-renal damage group. The two groups of blood pressure parameters were compared, and blood, β_2-MG level correlation analysis. Results Compared with non-renal impairment group (42 ± 8 mmHg) and (152 ± 10 mmHg), PP (58 ± 10 mmHg) and SBP (165 ± 28 mmHg) in renal impairment group were significantly increased. Correlation analysis showed that serum β_2-MG was positively correlated with PP and SBP, while urinary β_2-MG was positively correlated with PP, SBP, DBP and MAP. Which PP, SBP correlation is better. Conclusion PP and SBP, DBP, MAP increased can lead to early renal damage in patients with hypertension, and increased PP, SBP is the main factor leading to early renal damage in hypertensive patients.