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在荧光显微镜下观察新型光敏剂Ｒ藻红蛋白的荧光在肿瘤细胞中的分布，探讨以藻红蛋白为光敏药物的光动力损伤可能发生的细胞水平机制，以及培养液酸度和藻红蛋白浓度对其与细胞结合、进入及光动力杀伤的关系．结果表明在ｐＨ５ 时，藻红蛋白与瘤细胞有最好的结合．其结合部位随藻红蛋白浓度的增加，逐渐以分布在胞膜、胞浆和胞核为主，表现为一个动态进入细胞的过程．光动力杀伤作用与其进入细胞的数量成正相关，从形态学上证明了Ｒ藻红蛋白介导的光动力治疗作用与藻红蛋白进入瘤细胞状态紧密相关．
The fluorescence of the novel photosensitizer-R-phycoerythrin in the tumor cells was observed under a fluorescence microscope, and the possible cellular level mechanism of photodynamic damage with phycoerythrin as a photosensitizer was discussed, as well as the acidity and phycoerythrin of the culture solution. The concentration of its binding to cells, and the relationship between photodynamic killing. The results showed that phycoerythrin had the best binding to tumor cells at pH 5. The binding site gradually increases with the increase of phycoerythrin concentration in the cell membrane, cytoplasm, and nucleus, and shows a dynamic process of cell entry. The photodynamic killing effect is positively related to the number of cells entering the cell. Morphologically, it is proved that R phycoerythrin-mediated photodynamic therapy is closely related to the phycoerythrin entry into the neoplastic cells.