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目的探讨儿童患者结核分枝杆菌临床分离株的分子流行病学特征及与耐药关系。方法对2003年7月至2008年12月重庆医科大学附属儿童医院收集到的150株结核分枝杆菌,应用MIRU基因分型技术,并进行耐药测定,同时分析不同基因型与耐药之间的关系。结果 150株结核分枝杆菌分为89种基因型,其中包括65个单一型,24个成簇型.最大簇基因型为223325173533,耐药菌株在成簇类型和单一类型不存在差异统计学。结论 223325173533基因型菌株在重庆儿童中是社会传播的优势菌群,结核分枝杆菌的成簇与耐药无相关性.
Objective To investigate the molecular epidemiological characteristics of clinical isolates of Mycobacterium tuberculosis in children and its relationship with drug resistance. Methods A total of 150 strains of Mycobacterium tuberculosis collected from Children’s Hospital of Chongqing Medical University from July 2003 to December 2008 were genotyped by MIRU and tested for drug resistance. Relationship. Results One hundred and fifty Mycobacterium tuberculosis strains were divided into 89 genotypes, including 65 single type and 24 cluster type, and the largest cluster genotype was 223325173533. There was no statistical difference in the cluster type and single type among the resistant strains. Conclusion 223325173533 genotype strains in Chongqing children is the dominant community of social transmission, the clustering of tuberculosis and drug resistance was not related.