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目的探讨肝细胞生长因子(HGF)、结缔组织生长因子(CTGF)在糖尿病肾病发生、发展中的作用。方法检测微量白蛋白尿组、蛋白尿组、糖尿病组、对照组受检者空腹血糖、血肌酐及尿素氮以及血清HGF水平,并测定24h尿微量白蛋白和24h尿CTGF水平,并分析HGF、CTGF与尿微量白蛋白、血肌酐及尿素氮等指标之间的关系。结果微量白蛋白尿组、蛋白尿组患者血清HGF水平与糖尿病组、对照组比较,差异均有统计学意义(F=26.45,P<0.05)。微量白蛋白尿组和蛋白尿组患者尿CTGF水平与其他两组相比,差异均有统计学意义(F=320.896,P<0.05)。蛋白尿组尿CTGF水平与微量白蛋白尿组相比,差异有统计学意义(P<0.05)。血清HGF水平与尿微量白蛋白呈正相关(r=0.736,P<0.05),与血肌酐呈正相关(r=0.645,P<0.05)、与尿素氮呈正相关(r=0.621,P<0.05)。尿CTGF水平与尿微量白蛋白呈正相关(r=0.710,P<0.05)。血清HGF水平与尿CTGF水平呈正相关(r=0.650,P<0.05)。结论 HGF、CTGF与糖尿病肾病发生、发展有关,其检测对于早期诊断糖尿病肾病以及了解糖尿病患者肾损害程度提供了一定的参考价值,将给糖尿病肾病的治疗带来新的前景。
Objective To investigate the role of hepatocyte growth factor (HGF) and connective tissue growth factor (CTGF) in the occurrence and development of diabetic nephropathy. Methods The levels of fasting blood glucose, serum creatinine, blood urea nitrogen and serum HGF in patients with microalbuminuria, albuminuria, diabetes mellitus and control subjects were measured. The 24h urinary albumin and 24h urine CTGF levels were measured. The levels of HGF, CTGF and urinary albumin, serum creatinine and urea nitrogen and other indicators of the relationship. Results The levels of serum HGF in patients with microalbuminuria and proteinuria were significantly different from those in the diabetic group and the control group (F = 26.45, P <0.05). Compared with the other two groups, urinary CTGF levels in patients with microalbuminuria and proteinuria were significantly different (F = 320.896, P <0.05). Urinary CTGF level in albuminuria group was significantly higher than that in microalbuminuria group (P <0.05). Serum HGF levels were positively correlated with urine microalbumin (r = 0.736, P <0.05), and positively correlated with serum creatinine (r = 0.645, P <0.05), and positively correlated with urea nitrogen (r = 0.621, P <0.05). Urinary CTGF levels were positively correlated with urinary microalbumin (r = 0.710, P <0.05). Serum HGF levels were positively correlated with urinary CTGF levels (r = 0.650, P <0.05). Conclusion HGF and CTGF are related to the occurrence and development of diabetic nephropathy. The detection of HGF and CTGF may provide some reference value for the early diagnosis of diabetic nephropathy and the understanding of the degree of renal damage in diabetic patients, which will bring new prospects for the treatment of diabetic nephropathy.