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  5. Polyphosphorous acid catalyzed cyclization in the synthesis of cryptolepine derivatives

Polyphosphorous acid catalyzed cyclization in the synthesis of cryptolepine derivatives

来源 :中国化学快报（英文版） | 被引量 : 0次 | 上传用户：flame_earth
【摘 要】
：
11-Oxo-10,11-dihydroxy-5H-indolo[3,2,b]quinoline7-carboxylic acid was obtained specifically by polyphosphorous acid catalyzed cyclization with optimal reaction
【作 者】
：
Sheng Biao Wan Zhe Lin Liu Di 
【机 构】
：
Key Laboratory of Marine Drug,The Prevention Program
【出 处】
：
中国化学快报（英文版）
【发表日期】
：
2004年期
【关键词】
：
Cryptolepine Trioligomer Synthesis Proteasome 
【基金项目】
：
国家重点基础研究发展计划(973计划)
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论文部分内容阅读
11-Oxo-10,11-dihydroxy-5H-indolo[3,2,b]quinoline7-carboxylic acid was obtained specifically by polyphosphorous acid catalyzed cyclization with optimal reaction conditions. Biological assays showed that it potentially inhibits the proteasomal chymotrypsin-like activity in vitro and suppresses breast cancer cell growth.
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