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目的观察 2型糖尿病磺脲类降糖药继发性失效时改用胰岛素或加二甲双胍对空腹及餐后 2小时血糖、糖化血红蛋白的影响。方法 35例患者予以胰岛素 (诺和灵 30R)早、晚餐前两次皮下注射 ,监测空腹及餐后 2小时血糖 ,并根据需要加用二甲双胍口服。结果 8周后 2 5例患者空腹血糖及餐后 2小时血糖均达到理想控制 ,其余患者血糖均在可接受的范围内 ;空腹血糖 (FBG)、餐后 2小时血糖 (PBG)、糖化血红蛋白 (HbA1c)与治疗前相比有明显差别。结论大多数 2型糖尿病磺脲类降糖药继发性失效时 ,改用胰岛素或加二甲双胍治疗 ,对空腹及餐后 2小时血糖均能取得理想的控制。
Objective To observe the effects of insulin or metformin on type 2 diabetes mellitus (SSS) and hypoglycemic agents on fasting and 2-hour postprandial blood glucose and glycosylated hemoglobin (HbA1c) during secondary failure. Methods 35 patients were given insulin (norepinephrine 30R) twice daily before and after subcutaneous injection, monitoring of fasting and 2-hour postprandial blood glucose, and if necessary, plus oral metformin. Results After 8 weeks, the fasting blood glucose and 2-hour postprandial blood glucose of 25 patients achieved the ideal control. The remaining patients’ blood glucose was within the acceptable range. Fasting blood glucose (FBG), postprandial 2-hour blood glucose (PBG), glycosylated hemoglobin HbA1c) compared with before treatment there are significant differences. Conclusion Most type 2 diabetes sulfonyl hypoglycemic agents failed to switch to insulin or metformin treatment, the fasting and postprandial blood glucose 2 hours to obtain the desired control.