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目的 调查了解计划出院的慢性阻塞性肺疾病(慢阻肺)患者中不同原因所致单纯性夜间低氧血症的罹患率及相关危险因素,以便识别风险患者进行管理.方法 从我院呼吸内科2017年1月至6月计划出院的431例慢阻肺患者中筛选日间氧饱和度≥90％且符合纳入排除标准的患者.于出院日前两晚采用可穿戴便携式脉氧仪监测其整晚氧饱和度、脉搏、手动等数据,记录患者次日晨间临床症状、日间血气分析、肺功能、Epworth嗜睡评分(Epworth Sleepiness Score,ESS)、匹兹堡睡眠质量问卷(Pittsburgh Sleep Quality Index,PSQI)结果,将无夜间低氧血症、单纯性夜间低氧血症患者的以上数据进行对比分析.根据血氧曲线波形,将存在单纯性夜间低氧血症患者分为考虑慢阻肺-睡眠呼吸暂停低通气重叠综合征(overlap syndrome,OS)的患者与非OS夜间缺氧患者的以上指标进行对比.结果 共筛选出106例无日间缺氧的预出院慢阻肺患者,其中44例(41.5％)患者存在夜间低氧血症.夜间低氧的慢阻肺患者氧饱和度[(91.8±1.1)％比(94.4±1.5)％,P＜0.05]低于无夜间缺氧者,其中疑诊OS的患者较无夜间缺氧患者急性加重频率[(2.1±0.6)次/年比(1.4±0.4)次/年]、ESS评分[(10.5±2.7)分比(5.1±2.5)分]、PSQI[(12.8±4.4)分比(7.4±3.1)分]更高(P＜0.05).结论 在日间氧饱和度大于90％的预出院慢阻肺中,仍有约41.5％的患者存在单纯性夜间低氧血症.日间氧饱和度较低、存在日间嗜睡的患者更可能存在夜间低氧血症,OS患者有更高的年急性加重风险及嗜睡程度.应重视预出院慢阻肺患者夜间缺氧的筛查.“,”Objective To investigate the prevalence and risk factors of isolated nocturnal oxygen desaturation (INOD) in pre-discharge inpatients with chronic obstructive pulmonary disease (COPD).Methods Totally 431 inpatients with COPD in this department were screened during January to June in 2017,in which pre-discharge inpatients without daytime hypoxia were enrolled in this study.Portable and wearable oximeter was used to record whole night oxygen saturation,pulse,hand movement of the inpatients within two days before being discharged.The clinical characters and symptoms,resting daytime artery gas analysis results,spirometry results,Epworth Sleepiness Score (ESS),Pittsburgh Sleep Quality Index (PSQI) were recorded and compared between INOD and non-INOD patients.Moreover,these data were furtherly compared between patients with or without suspected COPD-SAHS overlap syndrome (OS) to reveal the differences in clinical features.Logistics regression was used to find out independent predictors.Results One hundred and six pre-discharge inpatients without daytime hypoxia were screened out and out of them,44 patients (41.5％) were proven with INOD.Patients with INOD presented lower daytime SaO2 [(91.8±1.1)％ vs.(94.4±1.5)％,P＜0.05],moreover,the patients with suspected OS had a higher yearly exacerbation frequency (2.1 ±0.6 per year vs.1.4±0.4 per year,P＜0.05),higher ESS score (10.5±2.7 vs.5.1±2.5,P＜0.05) and PSQI (12.8±4.4 vs.7.4±3.1,P＜0.05).Conclusions Even in pre-discharge COPD inpatients without daytime hypoxia,there is 41.5％ of them suffering from unrevealed INOD.Lower daytime oxygen saturation and higher ESS indicate probable INOD and with higher exacerbation risk in OS patients.To screen out INOD in pre-discharge COPD is of clinical value and in need of attention.