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目的探讨通心络胶囊联合阿司匹林治疗短暂性脑缺血发作的临床疗效。方法选取灵寿县中西医结合医院2015—2016年收治的短暂性脑缺血发作患者120例,随机分为对照组与治疗组,各60例。对照组患者予以阿司匹林治疗,治疗组患者在对照组基础上予以通心络胶囊治疗,两组患者均连续治疗1个月。比较两组患者临床疗效、血流动力学指标(全血黏度低切、全血黏度高切、血浆黏度及纤维蛋白)及不良反应发生情况。结果治疗组患者临床疗效优于对照组(P<0.05)。治疗前两组患者全血黏度低切、全血黏度高切、血浆黏度及纤维蛋白含量比较,差异无统计学意义(P>0.05);治疗后治疗组患者全血黏度低切、全血黏度高切、血浆黏度及纤维蛋白含量低于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论通心络胶囊联合阿司匹林治疗短暂性脑缺血发作的临床疗效确切,可有效改善患者血流动力学指标,且安全性高。
Objective To investigate the clinical effect of Tongxinluo capsule combined with aspirin in the treatment of transient ischemic attack. Methods 120 patients with transient ischemic attack admitted to Lingshou County Integrative Medicine Hospital from 2015 to 2016 were randomly divided into control group and treatment group, 60 cases each. The patients in the control group were treated with aspirin. The patients in the treatment group were given Tongxinluo capsule on the basis of the control group, and the patients in both groups were treated continuously for 1 month. Clinical efficacy, hemodynamic parameters (low whole blood viscosity, high whole blood viscosity, plasma viscosity and fibrin) and adverse reactions were compared between the two groups. Results The clinical efficacy of the treatment group was better than that of the control group (P <0.05). In the two groups before treatment, the whole blood viscosity, the whole blood viscosity, the plasma viscosity and the fibrin content had no statistical significance (P> 0.05). After treatment, the whole blood viscosity, High-cut, plasma viscosity and fibrin content were lower than those in the control group (P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion Tongxinluo capsule combined with aspirin in the treatment of transient ischemic attack has the exact clinical curative effect, which can effectively improve the hemodynamic parameters of patients with high safety.