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目的:观察神经节苷脂治疗新生儿缺氧缺血性脑病(HIE)的疗效及对TNF-α和IL-6的影响。方法:将78例HIE患儿随机分为两组,对照组39例仅采用常规治疗,观察组39例在常规治疗基础上应用神经节苷脂治疗,比较观察两组的临床效果、TNF-α和IL-6指标的变化。结果:观察组的总有效率为92.3%,对照组的总有效率为74.4%,两组比较差异有统计学意义(P<0.05)。观察组肌张力、反射和意识恢复天数均明显小于对照组,两组比较差异有统计学意义(P<0.05)。两组治疗后TNF-α和IL-6水平明显下降,与治疗前比较差异有统计学意义(P<0.05)。并且,观察组治疗后TNF-α和IL-6水平明显低于同期对照组(P<0.05)。结论:神经节苷脂对HIE进行治疗能够明显提高临床疗效,缩短张力、反射和意识恢复时间,降低血清TNF-α、IL-6水平,值得在临床推广应用。
Objective: To observe the efficacy of ganglioside in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE) and its effect on TNF-α and IL-6. Methods: 78 children with HIE were randomly divided into two groups. 39 cases in the control group were treated by conventional therapy only. The observation group was treated with ganglioside on the basis of routine treatment. The clinical effects, TNF-α And IL-6 index changes. Results: The total effective rate in the observation group was 92.3%, while the total effective rate in the control group was 74.4%. The difference between the two groups was statistically significant (P <0.05). The number of days of muscle tone, reflex and consciousness recovery in the observation group were significantly less than those in the control group, with significant difference between the two groups (P <0.05). The levels of TNF-α and IL-6 in the two groups were significantly decreased after treatment, with statistical significance (P <0.05). Moreover, the levels of TNF-α and IL-6 in the observation group were significantly lower than those in the control group (P <0.05). CONCLUSION: Gangliosides treatment of HIE can significantly improve the clinical efficacy, shorten the tension, reflex and consciousness recovery time, lower serum levels of TNF-α, IL-6, worth in the clinical application.