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过去曾有用卤泛曲林(halofantrine)治疗抗氯喹的恶性疟取得较好疗效的临床病例。本文旨在确定该药治疗恶性疟的有效剂量。患者55例,年龄19～56岁,男性41例,女性14例。其中41例居住法国、因回原藉国度假而得病,14例为法国旅游者,在流行区逗留1～3个月而感染恶性疟。所有患者均住院治疗。入院时及治疗后48小时测定血红蛋白,并作白细胞及血小板计数,临床生化包括肌酐、胆红质和SGPT,以及尿糖、蛋白检查。患者分成2组,第1组17例,卤泛曲林盐酸盐1天量为1 000mg,其中14例服
In the past, halofantrine was used to treat chloroquine-resistant falciparum malaria to obtain better clinical results. This article aims to determine the effective dose of the drug for the treatment of falciparum malaria. 55 patients, aged 19 to 56 years old, 41 males and 14 females. Of these, 41 cases were living in France, and were sick because of the national holiday on the island of Hanoi. Fourteen French tourists were fostered of falciparum malaria by staying in the endemic areas for 1-3 months. All patients were hospitalized. At admission and 48 hours after treatment, hemoglobin was measured and white blood cells and platelets were counted. Clinical biochemistry included creatinine, bilirubin and SGPT, as well as urine sugar and protein. Patients were divided into 2 groups, group 1, 17 cases, halobrotine hydrochloride 1 day volume of 1 000 mg, of which 14 cases of service