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本实验用多管微电极离子微电泳的方法,记录家兔尾核神经元的自发活动并测试其对微电泳吗啡类物质羟戊甲吗啡及其拮抗剂纳洛酮的反应,从161个单位的测试中,观察到有61个被羟戊甲吗啡所抑制,这种抑制可被纳洛酮所阻断(59/61)。对羟戊甲吗啡敏感的单位大多数分布在尾核头部背侧和边缘部分,与感觉调制的部位一致。纳洛酮可使部分处于安静状态的单位活动(7/34)。在46个单位中,观察到有24个对电针和羟戊甲吗啡的反应一致,其中16个均表现为自发活动的抑制。电针的抑制作用也可被纳洛酮所阻断(4/8)。支持电针作用部分与尾核内阿片肽系统有关的看法。
In this study, we used a multi-tube microelectrode ion micro-electrophoresis method to record the spontaneous activity of rabbit caudate nucleus neurons and test their response to morphine morphine and its antagonist naloxone, from 161 units Of the tests, 61 were observed to be inhibited by metformin, a finding that was blocked by naloxone (59/61). Most of the sensitive units of phenylephrine are located in the dorsal and marginal parts of the caudate nucleus, consistent with the site of sensory modulation. Naloxone allows some quiescent activity (7/34). Of the 46 units, 24 were observed consistent with electroacupuncture and phentolamine response, 16 of which showed inhibition of spontaneous activity. Electroacupuncture can also be blocked by naloxone (4/8). Supports the electro-acupuncture action part of the caudate nucleus opioid system-related views.