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[目的]观察四磨汤口服液对肝脾气滞证功能性消化不良(FD)患者血清、胃底、胃窦及十二指肠中NO、AchE、CCK、SP的影响。[方法]将符合纳入标准的FD患者60例,随机分为四磨汤+模拟多潘立酮治疗组30例和多潘立酮+模拟四磨汤对照组30例,治疗14d,观察治疗前后患者血清、胃底、胃窦及十二指肠中NO、AchE、CCK、SP变化情况。[结果]经过14d治疗后,四磨汤和多潘立酮均能降低FD患者血清、胃底、胃窦及十二指肠中NO、CCK的含量,提高FD患者血清、胃底、胃窦及十二指肠中AchE、SP的含量,从而调节FD患者胃肠运动,且四磨汤对FD患者胃肠激素的调节作用优于多潘立酮,2组相比差异有统计学意义(P<0.01或P<0.05)。[结论]四磨汤对FD患者血清、胃底、胃窦及十二指肠中NO、AchE、CCK、SP物质含量的调节,可能是其治疗肝脾气滞证FD的作用机制之一。
[Objective] To observe the effect of Siwengtan Oral Liquid on NO, AchE, CCK and SP in serum, gastric fundus, gastric antrum and duodenum of patients with functional dyspepsia (FD). [Methods] Sixty FD patients who met the inclusion criteria were randomly divided into four groups: 30 cases treated with Simotong + Mock Domperidone and 30 cases treated with Domperidone and Simvastatin. The patients were treated for 14 days. The levels of serum, Gastric antrum and duodenum NO, AchE, CCK, SP changes. [Results] After 14 days of treatment, both Sihuangtang and domperidone could reduce the levels of NO and CCK in serum, gastric fundus, gastric antrum and duodenum of patients with FD, increase the serum, gastric fundus, gastric antrum and 12 (P <0.01 or P <0.01 or P <0.01 or P <0.01 or P <0.01 or P <0.01 or P <0.01 or P < 0.05). [Conclusion] Si mill decoction regulates the contents of NO, AchE, CCK and SP in the serum, gastric fundus, gastric antrum and duodenum of patients with FD, which may be one of the mechanisms of FD for its treatment of FD.