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目的探讨多药耐药蛋白P糖蛋白(Pgp)、拓扑异构酶-Ⅱ(Top-Ⅱ)以及表皮生长因子受体(EGFR)在结直肠癌中的表达及意义。方法使用免疫组织化学法检测我院2015-01-2015-12入院结直肠癌组织患者的Pgp、Top-Ⅱ以及EGFR蛋白表达,并分析同病理参数之间的关系。结果无远隔转移组的Top-Ⅱ表达率高于远隔转移组,差异有统计学意义,P<0.05;Pgp以及EGFR表达同患者的年龄、性别、肿瘤位置、TNM分期、浸润深度无相关性,P>0.05。结论无远隔转移患者Top-Ⅱ在结直肠癌组织当中的表达较高,传统化疗耐药以及敏感患者肿瘤组织当中均存在西妥昔单抗靶点。
Objective To investigate the expression and significance of Pgp, Top-Ⅱ and epidermal growth factor receptor (EGFR) in colorectal cancer. Methods The expression of Pgp, Top-Ⅱ and EGFR in patients with colorectal cancer admitted from January 2015 to January 2015 in our hospital was detected by immunohistochemistry. The relationship between them and pathological parameters was analyzed. Results The expression rate of Top-Ⅱ in distant metastasis group was higher than that in distant metastasis group, the difference was statistically significant, P <0.05; Pgp and EGFR expression had no correlation with patient’s age, sex, tumor location, TNM stage and depth of invasion Sex, P> 0.05. Conclusion Top-Ⅱ in patients without distant metastasis is highly expressed in colorectal cancer tissues. CTC targets are found in both traditional chemotherapy-resistant and sensitive tumor tissues.