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目的通过临床实验探究血清降钙素原(PCT)在老年心力衰竭(心衰)合并肺炎患者抗感染治疗中的疗效。方法 98例老年心衰合并肺炎患者,根据治疗期间是否检测PCT水平分为检测组和未检测组,各49例。未检测组患者直接进行常规的抗感染治疗;检测组患者治疗期间检测PCT水平,根据检测结果随时调整抗感染治疗方法。比较两组患者治疗效果、治疗前后血清PCT水平、住院时间、住院费用及治疗期间检测组患者血清PCT水平。结果检测组患者治疗总有效率高于未检测组,差异具有统计学意义(P<0.05)。治疗前,检测组患者血清PCT水平为(3.4±0.1)g/L,未检测组为(3.3±0.2)g/L,两组比较差异无统计学意义(P>0.05)。治疗后,检测组患者血清PCT水平为(0.4±0.1)g/L,未检测组为(0.8±0.1)g/L,两组比较差异具有统计学意义(P<0.05)。结论通过测量PCT的含量可以评估老年心衰合并肺炎患者进行抗感染治疗的效果。
Objective To investigate the clinical efficacy of serum procalcitonin (PCT) in anti-infective therapy in elderly patients with heart failure (heart failure) complicated with pneumonia. Methods A total of 98 elderly patients with heart failure complicated with pneumonia were divided into test group and non-test group according to whether PCT level was detected during treatment, and 49 cases in each group. Undetected patients directly to conventional anti-infective treatment; detection of PCT patients during the treatment of PCT levels, according to the test results at any time to adjust the anti-infective treatment. The therapeutic effect was compared between the two groups. Before and after treatment, serum PCT level, hospital stay, hospitalization cost and serum PCT level in the test group during treatment were compared. Results The total effective rate of treatment group was higher than that of non-test group, the difference was statistically significant (P <0.05). Before treatment, serum PCT level was (3.4 ± 0.1) g / L in test group and (3.3 ± 0.2) g / L in non-test group, there was no significant difference between the two groups (P> 0.05). After treatment, the serum PCT level was (0.4 ± 0.1) g / L in the test group and (0.8 ± 0.1) g / L in the untreated group, with significant difference between the two groups (P <0.05). Conclusion The effect of anti-infective therapy on elderly patients with heart failure and pneumonia can be evaluated by measuring the content of PCT.