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Objective:Recent evidence suggests that Oct-4 is highly expressed in several cancers,and its expression contributes to tumor growth.In this study,we investigated the level of Oct-4 expression in rectal adenocarcinoma, and evaluated the prognostic significance of Oct-4 expression in these cases. Methods:The immunohistochemical expression of Oct-4 was evaluated in 52 formalin-fixed paraffin-embedded postoperative rectal adenocarcinoma tissue samples.The impact of the immunoreactivity of Oct-4 in regard to clinical outcome was determined by Kaplan-Meier and log-rank. Results:The expression level of Oct-4 ranged from 0 to 18.5%.There was no significant association between Oct-4 expression and gender(P=0.772),age(P=0.123),clinical stage(P=0.391),and histological grade(P=0.056). The 3-year local recurrence-free rates with negative and positive expression of Oct-4 were 83.5%and 75.0%, respectively(P=0.583).The 3-year metastasis-free rates with negative and positive expression of Oct-4 were 88.6% and 61.9%,respectively(P=0.035).The 3-year overall survival rates with negative and positive expression of Oct-4 were 77.9%and 49.0%,respectively(P=0.037). Conclusion:The results suggest that embryonic stem cell marker Oct-4 expression may have prognostic significance in patients with rectal adenocarcinoma.However,to confirm this more and larger studies are required.
Objective: Recent evidence suggests that Oct-4 is highly expressed in several cancers, and its expression contributes to tumor growth.In this study, we investigated the level of Oct-4 expression in rectal adenocarcinoma, and evaluated the prognostic significance of Oct-4. The expression of these cases. Methods:The immunohistochemical expression of Oct-4 was evaluated in 52 formalin-fixed paraffin-embedded postoperative rectal adenocarcinoma tissue samples.The impact of the immunoreactivity of Oct-4 in regard to clinical outcome was determined by Kaplan-Meier And log-rank. Results:The expression level of Oct-4 ranged from 0 to 18.5%.There was no significant association between Oct-4 expression and gender(P=0.772),age(P=0.123),clinical stage(P =0.391), his histological grade (P=0.056). The 3-year local recurrence-free rates with negative and positive expression of Oct-4 were 83.5% and 75.0%, respectively (P=0.583). The 3-year metastasis -free rates with negative and positive expression of Oct-4 were 88 .6% and 61.9%,respectively(P=0.035).The 3-year overall survival rates with negative and positive expression of Oct-4 were 77.9%and 49.0%,respectively(P=0.037).Conclusion:The results suggest that Embryonic stem cell marker Oct-4 expression may have prognostic significance in patients with rectal adenocarcinoma.However, to confirm this more and larger studies are required.