Endoscopic identification of Peyer's patches of the terminal ileum in a patient with Crohn'

• 作 者: Hiroshi Ishimoto Hajime lsomoto Saburo Shikuwa Takashi Suematu Masahiro Ito Ikuo Murata Hiromi Ishibashi Shigeru Kohno
• 机 构: Department of Internal Medicine National Nagasaki Medical Center,2-1001 Kubara,Omura,Nagasaki 856-85
• 出 处: World Journal of Gastroenterology
• 发表日期: 2004年18期
• 关键词: patches ulceration endoscopy villi longitudinal parenteral lymphoid nutrition gr

We presented a 20-year-old patient with Crohn’s disease(CD).Colonoscopy revealed longitudinal ulceration in theterminal ileum and rectal aphtoid ulcers.After treatmentwith mesalamine and total parenteral nutrition,repeatcolonoscopy revealed a granular elevated area in the terminalileum,which appeared as an irregular dome-like elevationwith irregularly arranged villi on magnifying endoscopy.Biopsyspecimens taken from the region showed microgranulomasand lymphoid hyperplasia,Scanning electron microscopyrevealed the presence of M cells,confirming that the areacorresponded to Peyer’s patches.Peyer’s patches bymagnifying endoscopy and electron microscopy may provideinsights into the pathogenesis of CD.

We presented a 20-year-old patient with Crohn’s disease (CD) .Colonoscopy revealed longitudinal ulceration in the terminal ileum and rectal aphtoid ulcers. After treatment with mesalamine and total parenteral nutrition, repeatcolonoscopy revealed a granular elevated area in the terminalileum, which appeared as an irregular dome-like elevationwith irregularly arranged villi on magnifying endoscopy. Biopsyspecimens taken from the region showed microgranulomas and lymphoid hyperplasia, Scanning electron microscopy reproduced the presence of M cells, confirming that the areacorresponded to Peyer’s patches. Peyer’s patches by magnifying endoscopy and electron microscopy may provideinsights into the pathogenesis of CD