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目的：观察穿心莲成分ＡＰＩ０１３４预防用药对动脉粥样硬化（ＡＳ）家兔血清一氧化氮（ＮＯ），血浆内皮素（ＥＴ）、环鸟苷酸（ｃＧＭＰ）、脂质过氧化物（ＬＰＯ）和超氧化物歧化酶（ＳＯＤ）的影响。方法：采用高胆固醇饲料喂饲另加牛血清白蛋白一次注射方法，建立家兔ＡＳ模型，随机分为对照组，模型组和ＡＰＩ０１３４用药组，各组在实验第４周和第８周取血标本测定上述参数。结果：与模型组比较，穿心莲成分ＡＰＩ０１３４预防用药４周及８周，均能提高ＮＯ、ｃＧＭＰ含量和ＳＯＤ活性（Ｐ＜０．０１），降低ＥＴ和ＬＰＯ含量（Ｐ＜０．０１）。结论：ＡＰＩ０１３４具有抗氧化、保护内皮功能和维持ＮＯ／ＥＴ平衡的作用。
OBJECTIVE: To observe the preventive effect of Andrographis paniculata API0134 on serum nitric oxide (NO), plasma endothelin (ET), cyclic guanosine monophosphate (cGMP), lipid peroxide (LPO) and atherosclerosis (AS) in rabbits. The effect of superoxide dismutase (SOD). METHODS: A high-cholesterol diet was fed together with one injection of bovine serum albumin. Rabbit AS models were established and randomly divided into control group, model group, and API0134 group. Blood was collected at the 4th and 8th week of the experiment. The specimen determines the above parameters. RESULTS: Compared with the model group, the preventive treatment of Andrographis paniculata API0134 at 4 weeks and 8 weeks could increase NO, cGMP content and SOD activity (P<0.01), and decrease ET and LPO content (P<0.01). Conclusion: API0134 has anti-oxidation, endothelial protection and maintains NO/ET balance.