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采用一步夹心固相酶免疫法测定正常人43例与糖尿病病人26例血清Ⅳ型胶原(CL-IV)的含量。结果表明,糖尿病病人血清中CL-IV含量显著高于正常对照组。尿蛋白阳性的糖尿病病人血清CL-IV含量显著高于尿蛋白阴性组。另外,血清CL-IV含量不受血压的影响。本文研究提示出血清CL-IV含量可作为监测糖尿病肾病(ON)的指标。
The levels of serum type Ⅳ collagen (CL-IV) in 43 normal subjects and 26 diabetic patients were determined by one-step sandwich enzyme immunoassay. The results showed that the serum of patients with diabetes CL-IV was significantly higher than the normal control group. Serum CL-IV levels in patients with urinary protein-positive diabetes were significantly higher than those in the urine-negative group. In addition, serum CL-IV levels are unaffected by blood pressure. Our study suggests that serum CL-IV levels can be used as indicators to monitor diabetic nephropathy (ON).