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目的:了解儿童IgA肾病临床病理与疗效。方法:将1987年2月～2010年6月住院经肾穿刺确诊的IgAN305例,结合临床表现,疗效进行分析。结果:隐匿性肾炎型100例(32.8%)、急性肾炎型65例(21.3%)、慢性肾炎型45例(14.8%)、单纯性肾病型36例(11.8%)、肾炎性肾病型58例(19.0%)、急进性肾炎型1例(0.3%)。完全缓解262例(85.9%)、好转39例(12.8%)、无效4例(1.3%),其中隐匿性肾炎型完全缓解91例(91.0%),好转9例(9.0%);急性肾炎型完全缓解63例(96.9%),好转2例(3.1%);慢性肾炎型完全缓解25例(55.6%),好转18例(40.0%),无效2例(4.4%);单纯性肾病型完全缓解35例(97.2%),好转1例(2.8%);肾炎性肾病型完全缓解48例(82.8%),好转8例(13.8%),无效2例(3.4%);急进性肾炎型1例好转(100.0%)。结论:以隐匿性肾炎型多见(32.8%),急性肾炎型21.3%,肾炎性肾病型19.0%,慢性肾炎型14.8%,单纯性肾病型11.8%,急进性肾炎型6.3%。疗效以单纯性肾病型、急性肾炎型、隐匿性肾炎较好,慢性肾炎型、肾炎性肾病型较差。
Objective: To understand the clinical pathology and curative effect of IgA nephropathy in children. Methods: The hospitalized from January 1987 to June 2010 were diagnosed by renal biopsy IgAN305 cases, combined with clinical manifestations, efficacy analysis. Results: There were 100 cases of occult nephritis (32.8%), 65 cases of acute nephritis (21.3%), 45 cases of chronic nephritis (14.8%), 36 cases of simple nephropathy (11.8%) and 58 cases of nephritic nephropathy (19.0%), 1 case of acute nephritis (0.3%). Complete remission was achieved in 262 cases (85.9%), improvement in 39 cases (12.8%), and ineffective in 4 cases (1.3%). Complete remission occured in 91 cases (91.0%) and improved in 9 cases (9.0% Complete remission was achieved in 63 cases (96.9%) and improvement in 2 cases (3.1%). Complete remission was found in 25 cases (55.6%) of chronic nephritis, 18 cases (40.0%) improved and 2 cases There were 48 cases (82.8%) of complete remission, 8 cases (13.8%) improved and 2 cases (3.4%) remission in 35 cases (97.2%) and 1 case Cases improved (100.0%). Conclusion: The occult nephritis is more common (32.8%), acute nephritis 21.3%, nephritis nephropathy 19.0%, chronic nephritis 14.8%, simple nephropathy 11.8%, and acute nephritis 6.3%. Efficacy of simple nephropathy, acute nephritis, occult nephritis is better, chronic nephritis, nephritis nephropathy worse.