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[目的]探讨艾素联合奥沙利铂、氟尿嘧啶治疗进展期胃癌患者的疗效及不良反应。[方法]将70例进展期胃癌患者随机分成观察组与对照组,观察组采用艾素联合奥沙利铂、氟尿嘧啶方案化疗,对照组采用奥沙利铂联合氟尿嘧啶方案化疗。[结果]观察组总有效率为54.3%,临床受益率为80.0%;对照组分别为31.4%和48.6%,两组比较差异有统计学意义(P﹤0.05)。两组患者的主要毒副反应有骨髓抑制、脱发、消化道反应、周围神经毒性等,但两组患者的毒副反应发生率差异无统计学意义(P均﹥0.05)。[结论]艾素联合奥沙利铂及氟尿嘧啶治疗两周方案对进展期胃癌患者有更好的疗效。
[Objective] To investigate the efficacy and side effects of combination of oxaliplatin and oxaliplatin and fluorouracil in patients with advanced gastric cancer. [Methods] Seventy patients with advanced gastric cancer were randomly divided into observation group and control group. The observation group was treated with combination of oxaliplatin and oxaliplatin and fluorouracil. The control group was treated with oxaliplatin plus fluorouracil chemotherapy. [Results] The total effective rate was 54.3% in the observation group and the clinical benefit rate was 80.0%. The control group was 31.4% and 48.6% respectively. There was significant difference between the two groups (P <0.05). There were no significant differences in the incidence of side effects between the two groups (P> 0.05). [Conclusion] Combination of alexin and oxaliplatin and fluorouracil for two weeks has a better curative effect on patients with advanced gastric cancer.