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目的探讨少腹逐瘀胶囊对慢性盆腔炎红细胞免疫功能的影响。方法选取2014年7月至2015年7月泰安市中医二院妇科门诊就诊的124例慢性盆腔炎患者为研究对象。按随机数字表法将患者分为观察组及对照组,各62例。对照组给予头孢拉定(每次0.5 g,每日4次)+甲硝唑片(每次0.1 g,每日4次)口服治疗,观察组在对照组基础上加服少腹逐瘀胶囊(每次3粒,每日3次),两组均7 d为1个疗程,持续治疗4个疗程,记录两组治疗效果,并观察两组治疗前后中医症状评分、红细胞免疫功能的变化。结果观察组治疗总有效率为96.77%(60/62),高于对照组的80.65%(50/62),差异有统计学意义(P<0.05)。观察组治疗后下腹痛[(0.92±0.10)分]、白带异常[(0.98±0.14)分]、带下气味[(0.97±0.13)分]、腰骶痛评分[(0.97±0.12)分]显著低于对照组的(2.18±0.29)分、(2.92±0.27)分、(2.56±0.22)分、(2.86±0.30)分,差异有统计学意义(P<0.01)。观察组免疫复合物花环率为(5.11±0.45)%,低于对照组的(7.25±0.89)%(P<0.01),而血红细胞C3b受体花环率为(6.88±1.22)%,高于对照组的(4.86±0.87)%,差异有统计学意义(P<0.01)。结论少腹逐瘀胶囊能有效提高慢性盆腔炎患者临床治疗效果,改善患者临床症状,其治疗机制可能通过调控红细胞免疫功能以增强机体免疫功能,达到治疗的目的。
Objective To investigate the effect of Shaofuzhuyu capsule on immune function of erythrocytes in chronic pelvic inflammatory disease. Methods A total of 124 patients with chronic pelvic inflammatory disease from gynecology clinic of the Second Hospital of Traditional Chinese Medicine from July 2014 to July 2015 were selected as the study subjects. The patients were divided into observation group and control group according to random number table method, each 62 cases. The control group was given cefradine (0.5 g each time, 4 times a day) + metronidazole tablets (0.1 g each time, 4 times a day) orally, the observation group was added on the basis of the control group Shaofuzhuyu capsule 3 times daily). Both groups were treated for 7 days for one course of treatment. Four courses of continuous treatment were used to record the therapeutic effect of the two groups. The symptom scores of Chinese medicine and the changes of erythrocyte immune function were observed before and after treatment. Results The total effective rate of the observation group was 96.77% (60/62), which was higher than that of the control group (80.65%, 50/62). The difference was statistically significant (P <0.05). Abdominal pain (0.92 ± 0.10), leucorrhea abnormality (0.98 ± 0.14), smell under the band (0.97 ± 0.13) and lumbosacral pain score (0.97 ± 0.12) (2.18 ± 0.29) points, (2.92 ± 0.27) points, (2.56 ± 0.22) points and (2.86 ± 0.30) points in the control group respectively. The difference was statistically significant (P <0.01). The rosette rate of immune complex in the observation group was (5.11 ± 0.45)%, which was lower than that of the control group (7.25 ± 0.89)% (P <0.01), while that of the red blood cell C3b receptor was (6.88 ± 1.22)% (4.86 ± 0.87)% in the control group, the difference was statistically significant (P <0.01). Conclusion Shaofuzhuyu Capsule can effectively improve the clinical effect of treatment in patients with chronic pelvic inflammatory disease and improve the clinical symptoms of patients. The therapeutic mechanism may be through the regulation of immune function of red blood cells to enhance immune function, to achieve the purpose of treatment.