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目的探讨８种Ｌ氨基酸合剂的肾功能保护作用及机理。方法雄性ＳＤ鼠静脉注射２ｍｌ氨基酸合剂后接受１０ｍｇ／ｋｇ顺铂，随后氨基酸以２ｍｌ／ｈ维持３小时，测定尿钠、钾浓度、肾小球滤过率（ＧＦＲ）及肾小管细胞线粒体呼吸功能。结果顺铂注射后３０分钟，尿钠、钾浓度分别增加５６％及２６倍。３小时后状态４呼吸升高１倍，状态３呼吸、呼吸控制率及氰化物解偶联呼吸分别减少４６％、７４％及４７％。该氨基酸合剂能增加ＧＦＲ８５％，改善肾小管钠、钾排泄异常，肾小管细胞线粒体呼吸障碍显著改善。结论该氨基酸合剂有明显的对抗顺铂肾毒性作用，增加ＧＦＲ，其机理可能通过改善受损细胞线粒体呼吸功能。
Objective To investigate the protective effects and mechanisms of 8 kinds of Lamino acids on renal function. Methods Male SD mice received intravenous injection of 2ml of amino acid mixture and received 10mg / kg of cisplatin. The amino acids were then maintained at 2ml / h for 3 hours. Urinary sodium and potassium concentrations, glomerular filtration rate (GFR) and mitochondria of renal tubular cells Breathing function. Results 30 minutes after cisplatin injection, urinary sodium and potassium concentrations increased 56% and 2.6 times, respectively. After 3 hours, state 4 respired by a factor of 2, state 3 respiration, respiration rate and cyanide uncouple respiration decreased by 46%, 74% and 47%, respectively. The amino acid mixture can increase GFR85%, improve renal tubular sodium and potassium excretion abnormalities, tubular mitochondrial respiratory disorders significantly improved. Conclusion The amino acid mixture has significant anti-cisplatin nephrotoxicity effect and increased GFR, and its mechanism may be through improving mitochondria respiratory function of damaged cells.