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目的:评价人工虫草制剂对血液透析终末期肾病患者微炎症及并发症的疗效。方法:选取2016年1—10月在医院血液净化中心维持性血液透析(Maintenance hemodialysis,MHD)治疗的70岁以上(含70岁)的终末期肾脏疾病患者46例,将其随机分为对照组和治疗组,每组23例;对照组患者给予规律性血液透析治疗,治疗组患者在对照组治疗的基础上加用人工虫草制剂治疗,比较两组患者治疗后微炎症、并发症的临床疗效。结果:治疗3月后治疗组患者血超敏C-反应蛋白(Hs-CRP)、白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)值均低于对照组(P<0.05),并发症的发生率也低于对照组(P<0.05);治疗组患者的改良定量量表(Modified quantitative subjective global assessment,MQSGA)评分值低于对照组(P<0.05)。结论:人工虫草制剂对维持性血液透析终末期肾病患者的微炎症和并发症的发生率均优于单用维持性血液透析的疗效。
Objective: To evaluate the curative effect of artificial Cordyceps preparation on micro-inflammation and complications in patients with end-stage renal disease. Methods: Forty-six patients with end-stage renal disease over the age of 70 (including 70 years old) who underwent maintenance hemodialysis (MHD) from January to October in 2016 were selected and randomly divided into control group And the treatment group, 23 cases in each group. The patients in the control group were given regular hemodialysis. The patients in the treatment group were treated with artificial Cordyceps on the basis of the control group. The clinical effects of micro-inflammation and complications were compared between the two groups . Results: After 3 months of treatment, the levels of Hs-CRP, IL-6 and TNF-α in the treatment group were lower than those in the control group (P < 0.05). The incidence of complications was also lower than that of the control group (P <0.05). The modified quantitative subjective global assessment (MQSGA) score of the treatment group was lower than that of the control group (P <0.05). Conclusion: The incidence of microinflammation and complication of artificial Cordyceps preparation in maintenance hemodialysis patients with end stage renal disease are better than that of maintenance hemodialysis alone.